A serotonin antagonist is a drug used to inhibit the action at serotonin receptors.
Many of the most important medications of this class selectively act at the 5-HT3 receptor, and thus are known as 5-HT3 antagonists. However, other drugs such as ketanserin act upon other types of serotonin receptors.
Antagonists of the 5-HT2A receptor are sometimes used as atypical antipsychotics, with the typical antipsychotics being purely dopamine antagonists.
'Ketanserine' blocks 5 HT2A,5 HT2C and alpha 1 receptors. 'Ondansetron,Dolansetron,Granisetron' are 5 HT3 receptor antagonist.they are efficacious in treating chemotherapy induced emesis. 'Clozapine' blocks 5 HT2A,5 HT2C,D4 receptors. 'Quetiapine' blocks 5 HT2A,5 HT1A,D1-2,HI,alpha 1 receptors. 'Methsergide' is 5 HT2A-2C antagonist and nonselective 5 HT 1 receptor blocker.it causes retrperitoneal fibrosis and mediastinal fibrosis. 'Cyproheptadine' blocks 5 HT2A, HI and it is a mild anticholinergic. 'Pizotifen' is a 5 HT2A-2C , H1 blocker and anticholinergic used for migraine prophylaxis
Many of the most important medications of this class selectively act at the 5-HT3 receptor, and thus are known as 5-HT3 antagonists. However, other drugs such as ketanserin act upon other types of serotonin receptors.
Antagonists of the 5-HT2A receptor are sometimes used as atypical antipsychotics, with the typical antipsychotics being purely dopamine antagonists.
'Ketanserine' blocks 5 HT2A,5 HT2C and alpha 1 receptors. 'Ondansetron,Dolansetron,Granisetron' are 5 HT3 receptor antagonist.they are efficacious in treating chemotherapy induced emesis. 'Clozapine' blocks 5 HT2A,5 HT2C,D4 receptors. 'Quetiapine' blocks 5 HT2A,5 HT1A,D1-2,HI,alpha 1 receptors. 'Methsergide' is 5 HT2A-2C antagonist and nonselective 5 HT 1 receptor blocker.it causes retrperitoneal fibrosis and mediastinal fibrosis. 'Cyproheptadine' blocks 5 HT2A, HI and it is a mild anticholinergic. 'Pizotifen' is a 5 HT2A-2C , H1 blocker and anticholinergic used for migraine prophylaxis
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